Randomised Prospective Controlled Trial of Topical 2 % Diltiazem Versus Lateral Internal Sphincterotomy for the Treatment of Chronic Fissure in Ano

Topical Diltiazem versus topical Glyceryl trinitrate (GTN) in the treatment of chronic anal fissure: Prospective study

evaluation of topical l-arginine gel and comparison with lateral internal sphincterotomy in treatment of chronic anal fissure

background: at present, surgery is the best method for chronic anal fissure, but by acquiring more knowledge about the pathogenesis and function of internal anal sphincter, non surgical treatment such as using of glycerin trinitrate, isosorbide, bethancol, diltiazem and butilinum toxin has been suggested. there is controversy about using of l-arginine. the aim of the present study was to compar...

Combined Tailored Lateral Internal Sphincterotomy with V- Y Advancement Flap Versus Lateral Internal Sphincterotomy Alone in Treatment of Chronic Anal Fissure

Background: Anal fissure is one of the most common ano-rectal diseases and 10% of patients ultimately receive surgery. Lateral internal sphincterotomy is highly effective and is the surgical treatment of choice for curing chronic anal fissure with hypertonicity after failure of conservative measures. LIS has a high success rate, but can have complications as bleeding and incontinence. There can...

Lateral subcutaneous internal sphincterotomy in the treatment of chronic anal fissure: our experience.

BACKGROUND Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonia favours fissure healing. Temporary reduction in sphincter tone can be achieved by conservative treatment. Surgical sphincterotomy achieves permanent reduction of sphincter hypertonia and is very successful at healing anal fissures, but requires an ope...

Comparative study of lateral internal sphincterotomy versus local 0.2% glyceryl trinitrate ointment for the treatment of chronic anal fissure.

The gold standard surgical treatment of chronic anal fissure is lateral internal sphincterotomy which lowers the resting anal pressure and effectively heals the majority of fissures. Local application of 0.2% glyceryl trinitrate ointment has been used as an agent for chemical sphincterotomy, causing temporary alleviation of sphincter spasm and allowing the fissure to heal without compromising t...